Publications:
A New Mechanism for Benzopyrone Formation in Aromatic Polyketide Biosynthesis
Zhang,
Wenju; Wilke, Burkhardt I.; Zhan, Jixun; Watanabe, Kenji; Boddy,* Christopher
N.; Tang,* Yi J.
Am. Chem. Soc. 2007, ASAP. (* Corresponding authors)
Sialic acid and N-acyl sialic acid analog production by fermentation of
metabolically and
genetically engineered Escherichia coli Lundgren, Benjamin L.; Boddy,
Christopher N. Org.
Biomol. Chem. 2007, 5, 1903-1909. (Evaluated by Faculty of 1000.)
The thioesterase domain from the pimaricin and erythromycin biosynthetic
pathways can
catalyze hydrolysis of simple thioester substrates. Sharma, Krishna K.;
Boddy, Christopher N.
Bioorg. Med. Chem. Lett. 2007, 17, 3034-3037.
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
Watanabe, Kenji;
Hotta, Kinya; Praseuth, Alex P.; Kotetsu, Kento; Migita, Akira; Boddy,
Christopher N.; Wang,
Clay C. C.; Oguri, Hiroki; Oikawa, Hideaki Nature Chemical Biology 2006,
2, 423-428.
Sweetening Cyclic Peptide Libraries. Boddy, Christopher N. Chem.
Biol. 2004, 11, 1599-1600.
Precursor-Directed Biosynthesis of Epothilone in Escherichia coli. Boddy,
Christopher N.;
Hotta, Kinya; Tse, Martha Lovato; Watts, R. Edward; Khosla, Chaitan. J.
Am. Chem. Soc. 2004,
7436-7437.
Understanding Substrate Specificity of Polyketide Synthase Modules by
Generating Hybrid
Multimodular Synthases. Watanabe, Kenji; Wang, Clay C. C.; Boddy, Christopher
N.; Cane,
David E.; Khosla, Chaitan J.
Biol. Chem. 2003, 278, 42020-42026.
Epothilone C Macrocyclization and Hydrolysis Are Catalyzed by the Isolated
Thioesterase
Domain of Epothilone Polyketide Synthase. Boddy, Christopher N.;
Schneider, Tanya; Hotta,
Kinya; Walsh, Christopher T.; Khosla, Chaitan J.
Am. Chem. Soc. 2003, 125, 3428-3429.
Atropselective Macrocyclization of Diaryl Ether Systems: Application
to the Synthesis of
Vancomycin. Nicolaou, K. C.; Boddy, Christopher N. C. J.
Am. Chem. Soc. 2002, 124,
10451-10455.
Extending Synthetic Access to Proteins with a removable acyl transfer
auxiliary. Offer, John;
Boddy, Christopher N. C.; Dawson, Philip E.
J. Am. Chem. Soc. 2002, 124, 4642-4646.
13.
Behind Enemy Lines. Nicolaou, K. C.; Boddy, Christopher N. C.
Scientific American 2001,
May, 54-61.
Does CIP nomenclature adequately handle molecules with multiple stereoelements?
A case
study of vancomycin and cognates. Nicolaou, K. C.; Boddy, Christopher
N. C.; Siegel, Jay S.
Angew. Chem. 2001, 113; 723-726; Angew.
Chem. Int. Ed. 2001, 40, 701-704.
Total Synthesis of Vancomycin: Part 2. Retrosynthetic Analysis, Synthesis
of Amino Acid
Building Blocks and Strategy Evaluations. Nicolaou, K. C.; Boddy,
Christopher N. C.; Li, Hui;
Koumbis, A. E.; Hughes, Robert; Natarajan, Swaminathan; Jain, Nareshkumar
F.; Ramanjulu,
Joshi M.; Bräse, Stefan; Solomon, Michael E. Chem.
Eur. J. 1999, 5, 2602-2621.
Total Synthesis of Vancomycin: Part 1. Design and Development of Methodology.
Nicolaou,
K. C.; Li, Hui; Boddy, Christopher N. C.; Ramanjulu, Joshi
M.; Yue, Tai-Yuen; Natarajan,
Swaminathan; Chu, Xin-Jie; Bräse, Stefan; Rübsam, Frank Chem.
Eur. J. 1999, 5, 2584-2601.
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics. Nicolaou,
K. C.; Boddy,
Christopher N. C.; Bräse, Stefan; Winssinger, Nicolas Angew.
Chem. 1999, 111, 2230-2287;
Angew. Chem. Int. Ed. 1999, 38, 2097-2152.
Total Synthesis of Vancomycin Aglycon - Part 1: Synthesis of Amino Acids
4-7 and
Construction of the AB-COD Ring Skeleton. Nicolaou, K. C.; Natarajan,
Swaminathan; Li, Hui;
Jain, Nareshkumar F.; Hughes, Robert; Solomon, Michael E.; Ramanjulu,
Joshi M.; Boddy,
Christopher N. C.; Takayanagi, Masaru Angew.
Chem. 1998, 110, 2872-2878; Angew. Chem. Int. Ed. 1998,
37, 2708-2714.
Probing the Ring Size of Epothilones: Total Synthesis of [14]-, [15]-,
[17]-, [18]-Epothilones
A. Nicolaou, K. C.; Sarabia, Francisco; Ninkovic, Sacha; Finlay, M. Ray
V.; Boddy, Christopher
N. C. Angew. Chem. 1998, 110, 85-89; Angew.
Chem. Int. Ed. 1998, 37, 81-84.
A Suzuki Coupling-macrolactamization Approach to the AB-COD Bi-cyclic
System of
Vancomycin. Nicolaou, K. C.; Ramanjulu, Joshi M.; Natarajan, Swaminathan;
Bräse, Stefan; Li,
Hui; Boddy, Christopher N. C.; Rübsam,
Frank Chem. Commun. 1997, 1899-1900.
New Technology for the Synthesis of Vancomycin-type Biaryl Ring Systems.
Nicolaou, K. C.;
Chu, Xin-Jie; Ramanjulu, Joshi M.; Natarajan, Swaminathan; Bräse,
Stefan; Rübsam, Frank;
Boddy, Christopher N. C. Angew.
Chem. 1997, 109, 1551-1552; Angew. Chem. Int. Ed. 1997, 36, 1539-1540.
New Synthetic Technology for the Synthesis of Aryl Ethers: Construction
of C-O-D and DO-
D Ring Model Systems of Vancomycin. Nicolaou, K. C.; Boddy, Christopher
N. C.;
Natarajan, Swaminathan; Yue, Tai-Yuen; Li, Hui; Bräse, Stefan; Ramanjulu,
Joshi M. J.
Am.
Chem. Soc. 1997, 119, 3421-3422.
Total Synthesis of Crystalline (±)-Fredericamycin A. Clive, Derrick
L. J.; Tao, Yong;
Khodabocus, Ahmad; Wu, Yong Jin; Angoh, A. Gaetan; Bennett, Sharon M.;
Boddy, Christopher
N.; Bordeleau, Luc; Cantin, Michel; Kleiner, Galit; Middleton, Donald
S.; Nichols, Christopher J.;
Richardson, Scott R.; Vernon, Peter G. Stud. Nat. Prod. Chem. 1995,
16, 27-74.
Total Synthesis of Crystalline (±)-Fredericamycin A. Use of Radical
Spirocyclization. Clive,
Derrick L. J.; Tao, Yong; Khodabocus, Ahmad; Wu, Yong Jin; Angoh, A. Gaetan;
Bennett,
Sharon M.; Boddy, Christopher N.; Bordeleau, Luc; Kellner, Dorit;
Kleiner, Galit; Middleton,
Donald S.; Nichols, Christopher J.; Richardson, Scott R.; Vernon, Peter
G. J.
Am. Chem. Soc.
1994, 116, 11275-11286.
Total Synthesis of (±)-Fredericamycin A. Use of Radical Spirocyclization.
Clive, Derrick L. J.;
Tao, Yong; Khodabocus, Ahmad; Wu, Yong Jin; Angoh, A. Gaetan; Bennett,
Sharon M.; Boddy,
Christopher N.; Bordeleau, Luc; Kellner, Dorit; Kleiner, Galit;
Middleton, Donald S.; Nichols,
Christopher J.; Richardson, Scott R.; Vernon, Peter G. J. Chem. Soc.,
Chem. Commun. 1992,
1489-1490.
Invited Lectures and Confrences:
2007
National Research Council of Canada
Natural Products Gordon Research Conference
Amherst College
State University of New York, Oswego
2006
Natural Products - Gordon Research Conference
Trans-Atlantic Frontiers in Chemistry
Syracuse University, Life Science building ground breaking
Seton Hall University
Worcester State College
Stonehill College
2005
Ithaca College
Youngstown State University
SUNY Environmental Science and Forestry
Hamilton College
2004
University of Cincinnati
Ithaca College
University of Toledo
McGill University
University of British Columbia
Washington University St. Louis
Cornell University
Vanderbilt University
The Ohio State University
2003
Duke University
University of Hawaii, Manoa
University at Buffalo
2002
Natural Products - Gordon Research Conference